sn‐1 Specificity of Lysophosphatidylcholine Acyltransferase‐1 Revealed by a Mass Spectrometry‐based Assay

Self‐Assembly of Selenium‐Doped Carbon Quantum Dots as Antioxidants for Hepatic Ischemia‐Reperfusion Injury Management

Profiling of branched-chain fatty acids via nitroxide radical-directed dissociation integrated on an LC-MS/MS workflow

By coupling O-benzylhydroxylamine derivatization and tandem mass spectrometry, nitroxide radical-induced dissociation can be initiated via collisional activation which enables the analysis of methyl branching(s) in fatty acids.

Bio-inspired lanthanum-ortho-quinone catalysis for aerobic alcohol oxidation: semi-quinone anionic radical as redox ligand

AbstractOxidation reactions are fundamental transformations in organic synthesis and chemical industry. With oxygen or air as terminal oxidant, aerobic oxidation catalysis provides the most sustainable and economic oxidation processes. Most aerobic oxidation catalysis employs redox metal as its active center. While nature provides non-redox metal strategy as in pyrroloquinoline quinone (PQQ)-dependent methanol dehydrogenases (MDH), such an effective chemical version is unknown. Inspired by the recently discovered rare earth metal-dependent enzyme Ln-MDH, here we show that an open-shell semi-quinone anionic radical species in complexing with lanthanum could serve as a very efficient aerobic oxidation catalyst under ambient conditions. In this catalyst, the lanthanum(III) ion serves only as a Lewis acid promoter and the redox process occurs exclusively on the semiquinone ligand. The catalysis is initiated by 1e--reduction of lanthanum-activated ortho-quinone to a semiquinone-lanthanum complex La(SQ-.)2, which undergoes a coupled O-H/C-H (PCHT: proton coupled hydride transfer) dehydrogenation for aerobic oxidation of alcohols with up to 330 h−1 TOF.

Pyridine dicarbanion-bonded Ag₁₃ organometallic nanoclusters: synthesis and on-surface oxidative coupling reaction

Unprecedented pyridine dicarbanion-bonded Ag13 nanoclusters were constructed according to a macrocycle-involved two-step synthetic protocol.

Deep-lipidotyping by mass spectrometry: recent technical advances and applications

Localization of Intrachain Modifications in Bacterial Lipids Via Radical-Directed Dissociation